Effects of Celastrus paniculatus Willd. and Sida cordifolia Linn. in Kainic Acid Induced Hippocampus Damage in Rats

Abstract:

Aim: The purpose of this study was to behavioral and neuroprotective efficacy of Celastrus paniculatus Willd. and Sida cordifolia Linn on hippocampus of the brain in kainic acid induced neurodegenerative diseases. Materials and Methods: A total of 30 albino Wistar rats were randomly divided into five groups: Vehicle control, kainic acid, kainic acid + seed oil of Celastrus paniculatus (SOCP), kainic acid + aqueous root extract of Sida cordifolia (ARESC), kainic acid + SOCP + ARESC. The following was analyzed in all groups: (a) Behavioral tests- Hole board test, Shuttle box test, Morris Water Maze test. (b)Blood parameters- RBC, WBC, Haemoglobin, Platelet count. (c)Serum parametersserum uric acid, serum cortisol, serum cholinesterase. Results: The kainic acid induced Alzheimer rats has shown significant changes towards normal behaviors. Total time spent in the dark chamber, no of head dips, time spent in head dips, latency to head dips, Number of rearing, latency of entrance (Sec) to the platform. The RBC count, platelet count, Hb content has shown a significant increase and WBC count has shown a significant decrease. A significant decrease in the serum cortisol and cholinesterase also shown by the rats treated with SOCP and ARESC as a mark of neuroprotection. Conclusion: SOCP and ARESC could be possibly used as anti-neurodegenerative agents for protecting hippocampus damage caused by kainic acid. However, further studies confirming its potential are certainly warranted.

Key words: Water maze test, Hole board test, Shuttle box test, Neuroprotection, Celastrus paniculatus, Sida cordifolia.